logo_fibro-targetsA new review was published by  Gyöngyösi et al. in European Journal of Heart Failure (2017) 19, 177-191; doi:10.1002/ejhf.696.

Greenpharma participated to this article for the in silico aspects. You can find the abstract below, and download the full version here.


Gyöngyösi M, Winkler J, Ramos I, Do QT, Firat H, McDonald K, González A, Thum T, Díez J, Jaisser F, Pizard A, Zannad F.

Myocardial fibrosis: biomedical research from bench to bedside

Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur
in response to cardiac ischaemic insults, systemic diseases, drugs, or any other harmful stimulus affecting the circulatory system or
the heart itself. Myocardial fibrosis alters the architecture of the myocardium, facilitating the development of cardiac dysfunction, also
inducing arrhythmias, influencing the clinical course and outcome of heart failure patients. Focusing on myocardial fibrosis may potentially improve patient care through the targeted diagnosis and treatment of emerging fibrotic pathways. The European Commission funded the
FIBROTARGETS consortium as a multinational academic and industrial consortium with the primary aim of performing a systematic and
collaborative search of targets of myocardial fibrosis, and then translating these mechanisms into individualized diagnostic tools and specific therapeutic pharmacological options for heart failure. This review focuses on those methodological and technological aspects considered
and developed by the consortium to facilitate the transfer of the new mechanistic knowledge on myocardial fibrosis into potential biomedical applications.

Keywords: Myocardial fibrosis, Animal models, Biomarkers, Cardiac imaging

European Journal of Heart Failure (2017) 19, 177–191

This work was supported by the European Commission FP7 Pro- gramme [FIBROTARGETS project grant HEALTH-20 1 3-6029047].

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