Services

Medicinal Chemistry

Chemistry collaborations with Greenpharma can be multifaceted as we have extensive expertise in:

  • Target-focused libraries building
  • Hemisynthetic libraries creation
  • Bioisostere scaffold design
  • Custom synthesis
  • Hit-to-lead optimisation
  • Patent exemplification

Our clients are in direct contact with a designated project manager (PhD) throughout the period of collaboration. Regular reporting is planned within the team, as well as with the client. In order to offer a wide flexibility to our customers, we use a Full Time Equivalent (FTE) schema. According to the contract agreement, we provide the client with a project team dedicated to the client’s needs for a specific period of time at a fixed rate per FTE.

NMR

The chemistry activity is supported by a cutting-edge analytical platform for quality control. This includes NMR, LC/MS, HPLC, Elemental Analysis, etc…

In lead optimisation project, we have a highly skilled team in molecular modelling that allows to leverage our expertise in medicinal chemistry.

Moreover, we have the abilities to work in milligram to tens of grams scales for fine chemicals. Upon submission of a request for custom synthesis, we will evaluate the chemistry and provide an estimated cost and delivery time.

Prof. Gérald Guillaumet, Orleans University, who is in our scientific board is a renowned expert in heterocyclic chemistry. He is one of our senior scientist consultant.

Example of achievement: Mimicking purine scaffold with pyrazolotriazine

We have developed several pyrazolo[1,5-a]-1,3,5-triazine focused libraries. The pyrazolo[1,5-a]-1,3,5-triazine ring behaves as a bioisostere of the purine ring. The substitution of the purine core by a pyrazolo[1,5-a]-1,3,5-triazine scaffold increases the stability towards nucleosidases that cleave the bond between the carbohydrate and the purine ring. Pyrazolotriazines are therefore interesting purine analogues whilst enhancing pharmacokinetic properties hence therapeutic interests. We have now on disposal a library of 80 pyrazolotriazine compounds.

Greenpharma S.A.S 3, allée du Titane - 45100 Orléans, France
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