Natural products
This is achieved with our expertise in pharmacognosy and reverse pharmacognosy and our ethnopharmacological database GPDB developed in-house that enable us to select the most promising molecules. Several studies demonstrated that natural compounds are more similar to in vivo active molecules than synthetic ones.
Active ingredient repositioning
Numerous compounds on the market are usually studied for a particular purpose, leaving unexplored other potential applications. Greenpharma uses its proprietary target database and Selnergy™ virtual screening tool to shift to other targets and to disclose other interesting applications. The delay of development is shortened as many data are already available eg safety, supply chain, regulatory…
Finding alternatives to synthetic compounds
A compound activity is related to the presence and/or absence of particular chemical fragments with a well-defined geometry. This will be reflected in its steric and electrostatic profiles (molecular topology). Greenpharma applies pharmacophore searching and molecular topology to identify natural version of synthetic compounds.
Compound association
Biological processes are complex and the current concept of ‘one molecule, one target’ is over-simplifying. Greenpharma proposes to associate known active compounds to increase their biological activities (synergy) in their former applications or in new applications. This is achieved by mining Greenpharma proprietary database GPDB and using Selnergy™.
