The characterisation of plant extracts is long and complex task. It usually reduced to the identification of several major compounds. Nevertheless, a deeper knowledge of the content of extracts is often necessary. GAINS (Greenpharma Automated Identification of Natural Structures) is a metabolomic tool developed by Greenpharma. Based on experimental data from LC/HRMS, GPDB database and an in silico fractionation tool, GAINS will suggest the most probable candidate molecules in the studied extract. It aims at obtaining structural information on all detectable compounds of a natural extract. Therefore it is possible to propose an identification of a large number of present compounds and open new development avenues.
Greenpharma offers its expertise and its technical resource to its customers to solve their problems in analytical chemistry. Greenpharma has a complete technical platform allowing quantitative and structural analyses:
- Separation techniques: HPLC with UV, ELSD and Electrochemical detectors, LC/MS and LC/MS/MS.
- Structural analysis: NMR, mass spectrometry, IR spectrometry, UV-Vis spectrometry, elemental analysis.
Greenpharma is specialised in the development of analysis methods to quantify molecules in plants or extracts, or to quantify endogenous molecules or unwanted molecules in a biological matrices. We have a long experience in the structural identification of natural compounds.
Hence, Greenpharma gives access to techniques and data at a very early stage; they are, so far, reserved to advanced development stages or to companies possessing an important analytical platform.
Greenpharma has a know-how and technical means to purify different types of natural substances. Along the process from the plant to the pure molecule, Greenpharma will use the best of the technology: conventional extraction methods that can be scaled up, supercritical CO2, subcritical water, HPLC preparative techniques…
Greenpharma adapts its strategies to customers goals:
- the development of a natural extract at an industrial scale and at a specific concentration of active substances;
- the design of an extract collection for biological screening;
- an activity-guided fractionation to identify the molecule responsible for a biological activity.