Greenpharma extract library (GPEL)
The Nature is rich in invention, we only reveal them, reinvent them.
Greenpharma is your R&D solutions provider, and offers you a wide range of products, services and active ingredients.
Our core business is based on the knowledge of natural substances and relies on a multidisciplinary technical platform, which allows this understanding of active molecules and the discovery of ingredients for the pharmaceutical, cosmetic or agri-food industries.
QSAR or QSPR respectively Quantitative Structure Activity or Property Relationship are powerful techniques consisting in using available structural data (translated into molecular descriptors) to derive a mathematical model. This model relates changes in the structure with an activity or a property.
QSAR techniques are successfully used in pharmacy for lead optimisation. QSPR can be applied to build models to estimate properties such as water solubility, logP, toxicity or organoleptic properties based on molecules with known properties.
Thanks to our global network of raw material suppliers, Greenpharma can help you identify the best sources for the development of your ingredients, taking into account costs, molecular content, sustainable development …
For example, you want a particular plant with a compound identified or containing a family of compounds. We ask the same plant from our partners and we analyze the content of interest molecules. Indeed, a plant that grows in several environments can produce different compounds at different levels.
A report is then provided for you to make a decision.
Greenpharma offers a wide range of products for research to development.
We provide several types of microplates in 96-well format for biological screening, you have the possibility to make “cherry picking”, find the standards for the reference molecules. We also supply the cosmetics industry with active ingredients.
Greenpharma launch a new active ingredient from primrose, the flower of spring and Nature revival. The extract significantly reduces the skin aging signs linked with chronicle stress induced by cortisol. What it does on the molecular level, is reflected in the cells and finally is visible on the skin:
Please feel free to contact us to get more information and to inquire a sample !
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In only one year, Greenpharma could improved its CSR score from 45 to 60 and awarded the silver medal (after the bronze) according to the rating system of EcoVadis.
This second evaluation confirms our commitment to the process of improving the crucial societal issues of environmental, labor, Human rights, ethics and sustainable procurement impacts.
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A recent study published on the Journal of Cosmetic Dermatology demonstrates that a black tulip extract (Dumaflorine) “improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied.”
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Hinoline C, our preservative-like active ingredient wins the 2022 innovation trophy by Cosmebio.
It was honored by a jury including 22 formulators among 17 other ingredients.
It can be used alone or as a preservative booster. Furthermore, we have demonstrated significant anti-acne properties in a clinical study vs placebo.
Hinoline C can be used as an anti-aging agent as it stimulates the expression of collagen 3 and the synthesis of hyaluronic acid.
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Biomimetic approach to the role of digeneaside in algae and its transposition to cosmetics
Autophagy and mitophagy are two natural biological mechanisms that are clearly involved in aging.
Autophagy is a mechanism that protects organs from chronic degeneration and extends lifespan in contributing to proteostasis and mitochondrial homeostasis [1]. Autophagic flow decreases with age in many organs [2] while its upward regulation is implicated in the extension of life through mitochondrial adaptation to stress [3]. Moreover, mitochondrial function plays a major role in numerous cellular pathways from ATP production to nuclear gene expression and epigenetic alterations. This mitochondrial function declines with age.
Recent articles [4,5] highlight the importance of mitophagy and autophagy in the cutaneaous cellular aging by endogenous (age-related) and exogenous (environmental stress) processes.
Digeneaside is a chemical compound naturally present in red algae such as Polysiphonia lanosa L. also known as « Pompon des ascophylles ». This compound acts as an osmo-regulator enabling the algae to manage the stress caused by salinity variation induced by its environment.
Like the algae in its environment and by biomimicry, we demonstrate a beneficial effect of digeneaside, or an algae extract containing it, on skin cells.
Indeed, the application of digeneaside on Normal Human Keratinocytes (NHK) and Fibroblasts (NHF) in various biological models showed that:
Like its natural role in algae (detoxifying saline osmolyte), digeneaside helps detoxify skin cells against external aggressions and allows to improve skin condition.
This is a good example of “pharmaco-mimicry”.
Come to meet our team at RICT at Lille :
You can contact them via Linkedin by clicking on their name.
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Since 2000, Greenpharma has been offering superior products and services to our customers, from SMEs to major international pharmaceutical, cosmetics, plant health, agri-food and petrochemical groups.
© 2019 Greenpharma SAS. Tous droits réservés.
