The Greenpharma natural chemical library combines our expertise in computational and medicinal chemistry, and our knowledge in pharmacognosy to create a unique source of diverse and pure compounds for hit/lead discovery. To built GPN, we gathered 450,000 natural compound structures in a database and used chemoinformatic tools to select a subset of chemically diverse and drug-like compounds.
We discarded amino acids, peptides, nucleic acids, long fatty chains, metals. We, then, carefully selected different phytochemical families in order to have as much family representatives as possible. A stock is maintained for each molecule to ensure further resupplies. GPN compounds are certified genuine natural compounds and information about the sources (e.g. family, genus, species, organ) are provided.
Hit & lead discovery, chemogenomics
Large chemical diversity, drug-like molecules, possibility of resupplies.
Library technical characteristics
Each microplate of this library is populated with 80 products. Each well contains 500µL (or 20µL) of a DMSO solution at 5mM of the products. This high concentration easily allows dilutions up to micromolar concentrations without the side toxicity effect of DMSO.
- Purity above 90 %
- Chemical diversity
- User-defined formatting in option
The library is supplied with an electronic file (e.g. SDF, XLS & PDF format) containing the structure, the name, the position of each product in the microplate, examples of natural sources producing the compounds and calculated physico-chemical descriptors.
Physico-chemical properties and phytochemistry distribution
The following table shows the physico-chemical profile and the phytochemistry distribution of GPNCL. Alkaloids are predominant as they represent a large and diverse phytochemical family followed by terpenes.